Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Macrophage ADAM17 deficiency augments CD36-dependent apoptotic cell uptake and the linked anti-inflammatory phenotype.

Circulation research - 21 Jun 2013

Driscoll Will S, Vaisar Tomas, Tang Jingjing, Wilson Carole L, Raines Elaine W

Abstract excerpt

RATIONALE: Apoptotic cell phagocytosis (efferocytosis) is mediated by specific receptors and is essential for resolution of inflammation. In chronic inflammation, apoptotic cell clearance is dysfunctional and soluble levels of several apoptotic cell receptors are elevated. Reports have identified proteolytic cleavage as a mechanism capable of releasing soluble apoptotic cell receptors, but the functional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADAM Proteins
Share to ADAM17 Protein
Share to CD36 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Culture Media, Conditioned

Share to Liposomes

Share to Macrophages, Peritoneal

Share to Peritonitis

Share to Thymocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 23584255
DOI: 10.1161/CIRCRESAHA.112.300683
PMCID: PMC3693752

Genes

ADAM17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Macrophage ADAM17 deficiency augments CD36-dependent apoptotic cell uptake and the linked anti-inflammatory phenotype.PMID 23584255Read ↗

Impaired Clearance of Apoptotic Cells in Chronic Inflammatory Diseases: Therapeutic ImplicationsSemantic proximity Read ↗

Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosisSemantic proximity Read ↗

Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice.Semantic proximity Read ↗

Efferocytosis and Its Role in Inflammatory DisordersSemantic proximity Read ↗

ADAM17 activity during human neutrophil activation and apoptosisSemantic proximity Read ↗

Clearance of apoptotic cells: implications in health and diseaseSemantic proximity Read ↗

Endothelial ADAM17 Promotes Neutrophil Migration and Pulmonary Microvascular Permeability in ARDSSemantic proximity Read ↗

The innate immune system and the clearance of apoptotic cellsSemantic proximity Read ↗

MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytesSemantic proximity Read ↗

The shedding protease ADAM17: Physiology and pathophysiologySemantic proximity Read ↗

Contribution of Defective PS Recognition and Efferocytosis to Chronic Inflammation and AutoimmunitySemantic proximity Read ↗

Efferocytosis Signaling in the Regulation of Macrophage Inflammatory ResponsesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.