Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease.

The Journal of comparative neurology - 6 Nov 2000

Mufson E J, Ma S Y, Cochran E J, Bennett D A, Beckett L A, Jaffar S, Saragovi H U, Kordower J H

Abstract excerpt

Recent studies indicate that there is a marked reduction in trkA-containing nucleus basalis neurons in end-stage Alzheimer's disease (AD). We used unbiased stereological counting procedures to determine whether these changes extend to individuals with mild cognitive impairment (MCI) without demen...

Topics

Join the communities discussing this publication.

Alzheimer Disease
Cell Count
Cognition Disorders
Nerve Degeneration
Nerve Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuropsychological Tests

Source

Identifiers

PMID: 11042589
DOI: 10.1002/1096-9861(20001106)427:1<19::aid-cne2>3.0.co;2-a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11042589-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease.PMID 11042589Read ↗

Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease.Semantic proximity Read ↗

Progression of age-associated cognitive impairment correlates with quantitative and qualitative loss of TrkA receptor protein in nucleus basalis and cortex.Semantic proximity Read ↗

Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's diseaseSemantic proximity Read ↗

Decreased trkA gene expression within basal forebrain neurons in Alzheimerʼs diseaseSemantic proximity Read ↗

<i>TrkA</i>Gene Ablation in Basal Forebrain Results in Dysfunction of the Cholinergic CircuitrySemantic proximity Read ↗

Paradoxical effect of TrkA inhibition in Alzheimer's disease models.Semantic proximity Read ↗

Differential modulation of the cholinergic phenotype of the nucleus basalis magnocellularis neurons by applying NGF at the cell body or cortical terminal fields.Semantic proximity Read ↗

Nerve growth factor and glial cell line-derived neurotrophic factor restore the cholinergic neuronal phenotype in organotypic brain slices of the basal nucleus of Meynert.Semantic proximity Read ↗

Neuronal Cell Death in Scrapie‐Infected Mice Is Due to ApoptosisSemantic proximity Read ↗

Neuronal Apoptosis in Creutzfeldt-Jakob DiseaseSemantic proximity Read ↗

Distribution of AMPA receptor subunits in the nucleus basalis of Meynert in aged humans: implications for selective neuronal degeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.