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Article

Decreased trkA gene expression within basal forebrain neurons in Alzheimerʼs disease

1 Dec 1996

Abstract excerpt

In situ hybridization for TrkA mRNA was combined with quantitative optical densitometry to evaluate whether the expression of this gene is altered within cholinergic basal forebrain neurons (CBF) in Alzheimer's disease (AD). TrkA mRNA within individual nucleus basalis neurons was significantly reduced (66%) in AD cases relative to aged controls. Reverse transcription polymerase chain reaction quantitative...

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PMID: 9051746
DOI: 10.1097/00001756-199612200-00006

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