Article
New variants in the mitochondrial genomes of schizophrenic patients.
European journal of human genetics : EJHG - 1 May 2006
Martorell Lourdes, Segués Teresa, Folch Gerard, Valero Joaquín, Joven Jorge, Labad Antonio, Vilella Elisabet
Abstract excerpt
The impaired mitochondrial function hypothesis in schizophrenia is based on evidence of altered brain metabolism, morphology, biochemistry and gene expression. Mitochondria have their own genome, which is needed to synthesize some of the subunits of the respiratory chain enzymes. Mitochondrial DNA (mtDNA) is maternally inherited and we observed an excess of maternal transmission of schizophrenia in a set of...
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