Article
Schizophrenia: maternal inheritance and heteroplasmy of mtDNA mutations.
Molecular genetics and metabolism - 1 Jan 2012
Ichikawa Tomoe, Arai Makoto, Miyashita Mitsuhiro, Arai Mayumi, Obata Nanako, Nohara Izumi, Oshima Kenichi, Niizato Kazuhiro, Okazaki Yuji, Doi Nagafumi, Itokawa Masanari
Abstract excerpt
Role of mitochondrial pathology in schizophrenia has not been fully clarified. We searched for distinctive variants in mtDNA extracted from the gray matter of postmortem brains and from peripheral blood samples. We screened mtDNA region containing 5 genes encoding subunits of cytochrome c oxidase and ATPases. Polymorphisms not already reported in databases are recorded as unregistered rare variants. Four...
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