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Article

Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster.

Pharmacogenetics and genomics - 1 Apr 2006

Alfirevic Ana, Mills Tracy, Harrington Pauline, Pinel Tracy, Sherwood James, Jawaid Ansar, Smith John C, March Ruth E, Barratt Bryan J, Chadwick David W, Kevin Park B, Pirmohamed Munir

Abstract excerpt

OBJECTIVES: The use of carbamazepine (CBZ), the most commonly prescribed antiepileptic drug, is hampered by the occurrence of severe, potentially lethal hypersensitivity reactions. The pathogenesis of hypersensitivity is not yet known, but immune mechanisms are involved. Predisposition to CBZ hypersensitivity is likely to be genetically determined, and genes within the major histocompatibility complex (MHC) have...

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Identifiers

PMID: 16538175
DOI: 10.1097/01.fpc.0000189800.88596.7a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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