Article

Carbamazepine hypersensitivity : linking metabolism to the immune response

2016-01-01

Abstract excerpt

Carbamazepine (CBZ) is an effective antiepileptic drug but has been associated with hypersensitivity reactions in up to 10% of patients. These reactions range from mild maculopapular exanthema to life-threatening conditions such as Stevens-Johnson syndrome and toxic epidermal necrolysis. The identification of CBZ-specific T cells and strong associations with specific human leukocyte antigen alleles provide evidenc...

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Literature Corpus work: eef8a04c-417f-57a4-912e-f285168a0e5e
DOI: 10.17638/03002243

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