Article
TNFalpha promoter region gene polymorphisms in carbamazepine-hypersensitive patients.
Neurology - 10 Apr 2001
Pirmohamed M, Lin K, Chadwick D, Park B K
Abstract excerpt
OBJECTIVE: To evaluate whether the major histocompatibility complex contains susceptibility genes for carbamazepine hypersensitivity. Carbamazepine hypersensitivity is immune-mediated, although factors determining its occurrence and severity are unknown. METHODS: Using PCR in 60 carbamazepine-hypersensitive patients, 37 with nonserious (Group I) and 23 with serious (Group II) reactions, and 313 control subjects...
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