Article
Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.
Pharmacogenetics and genomics - 1 Apr 2006
Hung Shuen-Iu, Chung Wen-Hung, Jee Shiou-Hwa, Chen Wen-Chieh, Chang Yun-Ting, Lee Woan-Ruoh, Hu Shu-Ling, Wu Meng-Tse, Chen Gwo-Shing, Wong Tak-Wah, Hsiao Pa-Fan, Chen Wei-Hsuan, Shih Han-Yu, Fang Wu-Hsiang, Wei Chun-Yu, Lou Yi-Hui, Huang Yau-Li, Lin Juei-Jueng, Chen Yuan-Tsong
Abstract excerpt
The anticonvulsant carbamazepine (CBZ) frequently causes cutaneous adverse drug reactions (cADRs), including maculopapular eruption (MPE), hypersensitivity syndrome (HSS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). We reported that SJS/TEN caused by CBZ is strongly associated with the HLA-B*1502 gene in Han Chinese. Here, we extended our genetic study to different types of CBZ-cADRs (91...
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