Article
Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population.
Human molecular genetics - 1 Mar 2011
Ozeki Takeshi, Mushiroda Taisei, Yowang Amara, Takahashi Atsushi, Kubo Michiaki, Shirakata Yuji, Ikezawa Zenro, Iijima Masafumi, Shiohara Tetsuo, Hashimoto Koji, Kamatani Naoyuki, Nakamura Yusuke
Abstract excerpt
An anticonvulsant, carbamazepine (CBZ), is known to show incidences of cutaneous adverse drug reactions (cADRs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome (DIHS). To identify a gene(s) susceptible to CBZ-induced cADRs, we conducted a genome-wide association study (GWAS) in 53 subjects with the CBZ-induced cADRs, including SJS, TEN and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.