Article
The major histocompatibility complex region marked by HSP70-1 and HSP70-2 variants is associated with clozapine-induced agranulocytosis in two different ethnic groups.
Blood - 15 Nov 1995
Corzo D, Yunis J J, Salazar M, Lieberman J A, Howard A, Awdeh Z, Alper C A, Yunis E J
Abstract excerpt
Genes of the major histocompatibility complex (MHC) have been associated with susceptibility to drug-induced adverse reactions. We previously found that clozapine-induced agranulocytosis (CA) is associated with the HLA-DRB1*0402, DRB4*0101, DQB1*0302, DQA1*0301 haplotype in Ashkenazi Jewish patie...
Topics
- Agranulocytosis
- Apoptosis
- Clozapine
- Disease Susceptibility
- Gene Frequency
- Genes, Dominant
- Genetic Markers
- Genetic Predisposition to Disease
- Genetic Variation
- HLA Antigens
- HSP70 Heat-Shock Proteins
- Haplotypes
- Humans
- Jews
- Major Histocompatibility Complex