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Article

Shared Genetic Risk Factors Across Carbamazepine-Induced Hypersensitivity Reactions.

Clinical pharmacology and therapeutics - 1 Nov 2019

Nicoletti Paola, Barrett Sarah, McEvoy Laurence, Daly Ann K, Aithal Guruprasad, Lucena M Isabel, Andrade Raul J, Wadelius Mia, Hallberg Pär, Stephens Camilla, Bjornsson Einar S, Friedmann Peter, Kainu Kati, Laitinen Tarja, Marson Anthony, Molokhia Mariam, Phillips Elizabeth, Pichler Werner, Romano Antonino, Shear Neil, Sills Graeme, Tanno Luciana K, Swale Ashley, Floratos Aris, Shen Yufeng, Nelson Matthew R, Watkins Paul B, Daly Mark J, Morris Andrew P, Alfirevic Ana, Pirmohamed Munir

Abstract excerpt

Carbamazepine (CBZ) causes life-threating T-cell-mediated hypersensitivity reactions, including serious cutaneous adverse reactions (SCARs) and drug-induced liver injury (CBZ-DILI). In order to evaluate shared or phenotype-specific genetic predisposing factors for CBZ hypersensitivity reactions, we performed a meta-analysis of two genomewide association studies (GWAS) on a total of 43 well-phenotyped Northern and...

Read the complete abstract on PubMed

Topics

Adult
Anaplastic Lymphoma Kinase
Carbamazepine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Chemical and Drug Induced Liver Injury

Drug Hypersensitivity

Drug Hypersensitivity Syndrome

Europe

Female

Genetic Predisposition to Disease

Genome-Wide Association Study

HLA-A Antigens

HLA-B Antigens

Humans

Male

Phenotype

Risk Factors

Stevens-Johnson Syndrome

Source

Open in PubMed Open full text

Identifiers

PMID: 31066027
DOI: 10.1002/cpt.1493
PMCID: PMC7156285

Genes

ALK

Provenance

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