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Characterization of Drug-Specific CD4+ T-Cells Reveals Possible Roles of HLA Class II in the Pathogenesis of Carbamazepine Hypersensitivity Reactions

19 Apr 2023

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide Carbamazepine (CBZ) is an aromatic anticonvulsant known to cause drug hypersensitivity reactions, which range in severity from relatively mild maculopapular exanthema to potentially fatal Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS–TEN). These reactions are known to be associated with human leukocyte antigen (HLA) class I alleles, and CBZ...

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PMID: 37074725
DOI: 10.1021/acs.chemrestox.2c00414

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