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Article

HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review.

Clinical pharmacology and therapeutics - 1 Dec 2012

Yip V L, Marson A G, Jorgensen A L, Pirmohamed M, Alfirevic A

Abstract excerpt

Carbamazepine (CBZ) therapy is associated with cutaneous adverse reactions in up to 10% of patients. Predisposition to these hypersensitivity reactions has been linked to the human leukocyte antigen (HLA) genotype. This systematic review determines the strength of these associations and accuracy of proposed genetic screening. We determined that carriage of HLA-B*1502 in Asian patients was associated with a pooled...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23132554
DOI: 10.1038/clpt.2012.189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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