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Article

Genetic variants associated with severe cutaneous adverse drug reactions induced by carbamazepine.

British journal of clinical pharmacology - 1 Feb 2022

Nakkam Nontaya, Konyoung Parinya, Amornpinyo Warayuwadee, Saksit Niwat, Tiamkao Somsak, Khunarkornsiri Usanee, Khaeso Kanyarat, Pattanacheewapull Oranuch, Jorns Teekayu Plangkoon, Chumworathayi Pansu, Tassaneeyakul Wichittra

Abstract excerpt

AIMS: Carbamazepine (CBZ) is one of the most common causative drugs of severe cutaneous adverse drug reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug reactions with eosinophilia and systemic symptoms. Although genetic polymorphisms of the human leucocyte antigens (HLA) are well recognized key elements for the susceptibility to CBZ-induced SCARs, some evidence...

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PMID: 34350628
DOI: 10.1111/bcp.15022

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