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Article

Asf1 links Rad53 to control of chromatin assembly.

Genes & development - 1 May 2001

Hu F, Alcasabas A A, Elledge S J

Abstract excerpt

Yeast defective in the checkpoint kinase Rad53 fail to recover from transient DNA replication blocks and synthesize intact chromosomes. The effectors of Rad53 relevant to this recovery process are unknown. Here we report that overproduction of the chromatin assembly factor Asf1 can suppress the Ts phenotype of mrc1rad53 double mutants and the HU sensitivity of rad53 mutants. Eliminating silencing also suppresses...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11331602
DOI: 10.1101/gad.873201
PMCID: PMC312686

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Asf1 links Rad53 to control of chromatin assembly.PMID 11331602Read ↗

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Regulation of histone deposition proteins Asf1/Hir1 by multiple DNA damage checkpoint kinases in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1.Semantic proximity Read ↗

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Histone chaperone ASF1 cooperates with the Brahma chromatin-remodelling machinery.Semantic proximity Read ↗

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