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Article

Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor.

The EMBO journal - 1 Nov 1996

Galzi J L, Bertrand S, Corringer P J, Changeux J P, Bertrand D

Abstract excerpt

The divalent cation calcium potentiates the physiological response of neuronal nicotinic receptors to agonists by enhancing ionic current amplitudes, apparent agonist affinity and cooperativity. Here we show that mutations in several consensus Ca2+ binding sequences from the N-terminal domain of the neuronal alpha 7 nicotinic acetylcholine receptor alter Ca2+ potentiation of the alpha 7-V201-5HT3 chimera....

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Identifiers

PMID: 8918460
PMCID: PMC452330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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