Article
Interleukin-1 receptor-associated kinase 3 gene associates with susceptibility to acute lung injury.
American journal of respiratory cell and molecular biology - 1 Oct 2011
Pino-Yanes María, Ma Shwu-Fan, Sun Xiaoguang, Tejera Paula, Corrales Almudena, Blanco Jesús, Pérez-Méndez Lina, Espinosa Elena, Muriel Arturo, Blanch Lluis, Garcia Joe G N, Villar Jesús, Flores Carlos
Abstract excerpt
Sepsis is the most common cause of acute lung injury (ALI), leading to organ dysfunction and death in critically ill patients. Previous studies associated variants of interleukin-1 receptor-associated kinase genes (IRAKs) with differential immune responses to pathogens and with outcomes during sepsis, and revealed that increased expression levels of the IRAK3 gene were correlated with poor outcomes during sepsis....
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