Article
Contribution of haplotypes across the fibrinogen gene cluster to variation in risk of myocardial infarction.
Thrombosis and haemostasis - 1 Mar 2005
Mannila Maria Nastase, Eriksson Per, Lundman Pia, Samnegård Ann, Boquist Susanna, Ericsson Carl-Göran, Tornvall Per, Hamsten Anders, Silveira Angela
Abstract excerpt
Fibrinogen has consistently been recognized as an independent predictor of myocardial infarction (MI). Multiple mechanisms link fibrinogen to MI; therefore disentangling the factors underlying variation in plasma fibrinogen concentration is essential. Candidate regions in the fibrinogen gamma (FGG), alpha (FGA) and beta (FGB) genes were screened for single nucleotide polymorphisms (SNPs). Several novel SNPs were...
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