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Article

Polymorphisms in chemokine and chemokine receptor genes and the development of coal workers' pneumoconiosis.

Cytokine - 7 Feb 2006

Nadif Rachel, Mintz Margaret, Rivas-Fuentes Selma, Jedlicka Anne, Lavergne Elise, Rodero Mathieu, Kauffmann Francine, Combadière Christophe, Kleeberger Steven R

Abstract excerpt

Chemokines and their receptors are key regulators of inflammation and may participate in the lung fibrotic process. Associations of polymorphisms in CCL5 (G-403A) and its receptor CCR5 (Delta32), CCL2 (A-2578G) and CCR2 (V64I), and CX3CR1 V249I and T280M with coal worker's pneumoconiosis (CWP) were investigated in 209 miners examined in 1990, 1994 and 1999. Coal dust exposure was assessed by job history and...

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Source

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Identifiers

PMID: 16524739
DOI: 10.1016/j.cyto.2006.01.001
PMCID: PMC1913495

Genes

CCR5
CCL2
CCL5
CCR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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