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MUC5B promoter polymorphisms and risk of coal workers' pneumoconiosis in a Chinese population.

Molecular biology reports - 1 Jul 2014

Ji Xiaoming, Wu Baiqun, Jin Kexin, Luo Chen, Han Ruhui, Chen Minjuan, Hou Zhiguo, Fan Jingjing, Ni Chunhui

Abstract excerpt

Coal workers' pneumoconiosis (CWP) is characterized by fibrosing nodular lesions that eventually develop into progressive pulmonary fibrosis. Genetic variations have been recognized to be involved in the multi-factorial susceptibility to CWP, and MUC5B is a candidate lung fibrosis susceptibility gene. In the present study, we investigated possible genetic associations between three single nucleotide polymorphisms...

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PMID: 24924948
DOI: 10.1007/s11033-014-3100-2

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