Article
IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal miners.
The European respiratory journal - 1 Dec 2006
Nadif R, Mintz M, Marzec J, Jedlicka A, Kauffmann F, Kleeberger S R
Abstract excerpt
It has been suggested that interleukin (IL)-18 plays a role in the development of inflammatory and fibrosing lung diseases. Associations of polymorphisms in the genes coding for IL-18 (IL18 /G-656T, C-607A, G-137C, T113G, C127T) and its receptor (IL18R1 /C-69T) with coal workers' pneumoconiosis (CWP) were studied in 200 miners who were examined in 1990, 1994 and 1999. Coal-dust exposure was assessed according to...
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