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Article

Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch.

The EMBO journal - 8 Feb 2006

Guthridge Mark A, Powell Jason A, Barry Emma F, Stomski Frank C, McClure Barbara J, Ramshaw Hayley, Felquer Fernando A, Dottore Mara, Thomas Daniel T, To Bik, Begley C Glenn, Lopez Angel F

Abstract excerpt

Pleiotropism is a hallmark of cytokines and growth factors; yet, the underlying mechanisms are not clearly understood. We have identified a motif in the granulocyte macrophage-colony-stimulating factor receptor composed of a tyrosine and a serine residue that functions as a binary switch for the independent regulation of multiple biological activities. Signalling occurs either through Ser585 at lower cytokine...

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Source

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Identifiers

PMID: 16437163
DOI: 10.1038/sj.emboj.7600948
PMCID: PMC1383532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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