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Article

IL10 and IL12B polymorphisms each influence IL-12p70 secretion by dendritic cells in response to LPS.

Immunology and cell biology - 1 Apr 2006

Peng Judy C, Abu Bakar Sazaly, Richardson Michelle M, Jonsson Julie J, Frazer Ian H, Nielsen Lars K, Morahan Grant, Thomas Ranjeny

Abstract excerpt

Dendritic cells (DC) are the main producers of the cytokine IL-12p70, through which they play a direct role in the development of IFN-gamma-secreting Th1 cells, costimulation of CTL differentiation and NK-cell activation. In contrast, IL-10, which is also produced by DC, negatively regulates IL-12 production. IL-12p70 production varies widely between individuals, and several polymorphisms in the gene encoding...

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PMID: 16519741
DOI: 10.1111/j.1440-1711.2006.01419.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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