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Article

A polymorphism in the coding region of Il12b promotes IL-12p70 and IL-23 heterodimer formation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2011

Zwiers Antonie, Fuss Ivan J, Seegers Diana, Konijn Tanja, Garcia-Vallejo Juan J, Samsom Janneke N, Strober Warren, Kraal Georg, Bouma Gerd

Abstract excerpt

IL-12 and IL-23 are heterodimeric cytokines involved in the induction of Th1 and Th17 immune responses. Previous work indicated that a region on chromosome 11 encoding the IL-12p40 subunit regulates strain differences in susceptibility to murine trinitrobenzene sulfonic acid-induced colitis. In addition, this region determines strain differences in LPS-induced IL-12 responses. In this study, we investigated how...

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Identifiers

PMID: 21321105
DOI: 10.4049/jimmunol.1001330
PMCID: PMC3673698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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