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Article

Transgenic studies of pain and analgesia: mutation or background genotype?

The Journal of pharmacology and experimental therapeutics - 1 May 2001

Lariviere W R, Chesler E J, Mogil J S

Abstract excerpt

The application of transgenic (knockout) technology to the study of pain is rapidly expanding. Despite its power, this technique has several shortcomings that complicate the interpretation of the data obtained. Although compensation by other genes is a well recognized problem, issues related to the background genotype of the mutant mice are less well appreciated. This review describes these confounds as they...

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PMID: 11303031

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