Genetics of murine leishmaniasis.

doi:10.1093/bfgp/4.3.270

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Article

Genetics of murine leishmaniasis.

Briefings in functional genomics & proteomics - 1 Nov 2005

Foote Simon J, Handman Emanuela

Abstract excerpt

Leishmaniasis encompasses a number of disease syndromes, caused by several species of the digenetic protozoan Leishmania, and is transmitted by sandflies. The mouse model of the disease has been used to identify genes involved in disease susceptibility--for example, the Slc11a1 gene, important in resistance to Leishmania donovani--and to map loci important in Leishmania major infection. The genetics of the host...

Topics

Animals
Chromosome Mapping
Epistasis, Genetic
Genetic Predisposition to Disease
Leishmania donovani
Leishmania major
Leishmaniasis
Macrophages
Mice
Models, Genetic
Nitric Oxide Synthase Type II
Species Specificity
T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 16420752
DOI: 10.1093/bfgp/4.3.270

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