Article
Adherence as a predictor of the development of class-specific resistance mutations: the Swiss HIV Cohort Study.
PloS one - 1 Jan 2013
von Wyl Viktor, Klimkait Thomas, Yerly Sabine, Nicca Dunja, Furrer Hansjakob, Cavassini Matthias, Calmy Alexandra, Bernasconi Enos, Böni Jürg, Aubert Vincent, Günthard Huldrych F, Bucher Heiner C, Glass Tracy R
Abstract excerpt
BACKGROUND: Non-adherence is one of the strongest predictors of therapeutic failure in HIV-positive patients. Virologic failure with subsequent emergence of resistance reduces future treatment options and long-term clinical success. METHODS: Prospective observational cohort study including patients starting new class of antiretroviral therapy (ART) between 2003 and 2010. Participants were naïve to ART class and...
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