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Article

The HIV-1 integrase genotype strongly predicts raltegravir susceptibility but not viral fitness of primary virus isolates.

AIDS (London, England) - 2 Jan 2010

Buzón Maria José, Dalmau Judith, Puertas Maria Carmen, Puig Jordi, Clotet Bonaventura, Martinez-Picado Javier

Abstract excerpt

OBJECTIVE: : Resistance to raltegravir is associated with three genetic pathways defined by the mutations Y143R/C, Q148H/R/K or N155H in integrase, which also infer a viral fitness cost. Additionally, the three major HIV-1 drug-targeted enzymes protease, reverse transcriptase and integrase mature from the same polyprotein, suggesting the potential for interaction between them. This study aims to elucidate the...

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Source

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PMID: 19770695
DOI: 10.1097/QAD.0b013e328331c81e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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