Article

Role of GLIS3 in thyroid development and in the regulation of gene expression in thyroid specific Glis3KO mice

2023-07-07

Abstract excerpt

<title>Abstract</title> <p>Loss of GLI-Similar 3 (GLIS3) function in mice and humans causes congenital hypothyroidism (CH). In this study, we demonstrate that GLIS3 protein is first detectable at E15.5 of murine thyroid development, a time when GLIS3 target genes, such as <italic>Slc5a5</italic> (<italic>Nis</italic>), become also expressed. We further show that <italic>Glis3</italic>KO mice do not display any ma...

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Literature Corpus work: 9f04c995-7e89-5771-a642-d21432171bb2
DOI: 10.21203/rs.3.rs-3044388/v1

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