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Article

The Histone H3K9 Demethylase Kdm3b Is Required for Somatic Growth and Female Reproductive Function

1 Jan 2015

Abstract excerpt

Kdm3b is a Jumonji C domain-containing protein that demethylates mono- and di-methylated lysine 9 of histone H3 (H3K9me1 and H3K9me2). Although the enzyme activity of Kdm3b is well characterized in vitro, its genetic and physiological function remains unknown. Herein, we generated Kdm3b knockout (Kdm3bKO) mice and observed restricted postnatal growth and female infertility in these mice. We found that Kdm3b...

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PMID: 25892958
DOI: 10.7150/ijbs.11849

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