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Article

Krüppel-like factor 5 is important for maintenance of crypt architecture and barrier function in mouse intestine.

Gastroenterology - 1 Oct 2011

McConnell Beth B, Kim Samuel S, Yu Ke, Ghaleb Amr M, Takeda Norifumi, Manabe Ichiro, Nusrat Asma, Nagai Ryozo, Yang Vincent W

Abstract excerpt

BACKGROUND & AIMS: Krüppel-like factor 5 (KLF5) is transcription factor that is expressed by dividing epithelial cells of the intestinal epithelium. KLF5 promotes proliferation in vitro and in vivo and is induced by mitogens and various stress stimuli. To study the role of KLF5 in intestinal epithelial homeostasis, we examined the phenotype of mice with conditional deletion of Klf5 in the gut. METHODS: Mice were...

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Identifiers

PMID: 21763241
DOI: 10.1053/j.gastro.2011.06.086
PMCID: PMC3186863

Genes

KLF5

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