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Article

Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation.

The Journal of biological chemistry - 23 Nov 2007

Evans Paul M, Zhang Wen, Chen Xi, Yang Jun, Bhakat Kishor K, Liu Chunming

Abstract excerpt

Colon cancer is the second leading cause of cancer death in the United States. Krüppel-like factor 4 (KLF4) is a transcription factor involved in both proliferation and differentiation in the colon. It is down-regulated in both mouse and human colonic adenomas and has been implicated as a tumor suppressor in the gut, whereas in breast cancer, KLF4 is an oncogene. KLF4 is also involved in reprogramming...

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Source

Identifiers

PMID: 17908689
DOI: 10.1074/jbc.M701847200

Genes

KLF4
HDAC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation.PMID 17908689Read ↗

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