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Article

Haploinsufficiency of Krüppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestine.

Cancer research - 15 May 2009

McConnell Beth B, Bialkowska Agnieszka B, Nandan Mandayam O, Ghaleb Amr M, Gordon Frank J, Yang Vincent W

Abstract excerpt

Inactivation of the tumor suppressor adenomatous polyposis coli, with the resultant activation of beta-catenin, is the initiating event in the development of a majority of colorectal cancers. Krüppel-like factor 5 (KLF5), a proproliferative transcription factor, is highly expressed in the proliferating intestinal crypt epithelial cells. To determine whether KLF5 contributes to intestinal adenoma formation, we...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19435907
DOI: 10.1158/0008-5472.CAN-08-4402
PMCID: PMC2702486

Genes

KLF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haploinsufficiency of Krüppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestine.PMID 19435907Read ↗

Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations.Semantic proximity Read ↗

KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis.Semantic proximity Read ↗

Krüppel-like factor 5 is important for maintenance of crypt architecture and barrier function in mouse intestine.Semantic proximity Read ↗

Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of ApcMin/+ MiceSemantic proximity Read ↗

Tgfbr1 Haploinsufficiency Is a Potent Modifier of Colorectal Cancer DevelopmentSemantic proximity Read ↗

Krüppel-like factor 5 protects against murine colitis and activates JAK-STAT signaling in vivo.Semantic proximity Read ↗

PWD/Ph-Encoded Genetic Variants Modulate the Cellular Wnt/β-Catenin Response to Suppress Apc Min-Triggered Intestinal Tumor Formation.Semantic proximity Read ↗

Induction of inflammatory bowel disease accelerates adenoma formation in Min +/- mice.Semantic proximity Read ↗

Deletion of the WNT Target and Cancer Stem Cell Marker CD44 in Apc(Min/+) Mice Attenuates Intestinal TumorigenesisSemantic proximity Read ↗

Krüppel-Like Factor 5 Mediates Cellular Transformation During Oncogenic KRAS-Induced Intestinal TumorigenesisSemantic proximity Read ↗

Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression.Semantic proximity Read ↗

Krüppel-like factor 5 mediates transmissible murine colonic hyperplasia caused by Citrobacter rodentium infection.Semantic proximity Read ↗

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