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Article

Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study.

Arthritis research & therapy - 1 Jan 2006

Butt Christopher, Peddle Lynette, Greenwood Celia, Hamilton Sean, Gladman Dafna, Rahman Proton

Abstract excerpt

Recent studies have implicated PTPN22 and tp53 in susceptibility to several autoimmune diseases, including rheumatoid arthritis, suggesting that these genes are important in maintaining immune homeostasis. Because autoimmune diseases may share similar susceptibility loci, investigation of these genes in psoriatic arthritis (PsA) is of potential relevance. As a result we investigated known coding polymorphisms in...

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Source

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Identifiers

PMID: 16507123
DOI: 10.1186/ar1880
PMCID: PMC1526561

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study.PMID 16507123Read ↗

Association of the PTPN22 locus with rheumatoid arthritis in a New Zealand Caucasian cohort.Semantic proximity Read ↗

PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus.Semantic proximity Read ↗

Genetic Polymorphism of PTPN22 in Autoimmune Diseases: A Comprehensive Review.Semantic proximity Read ↗

Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene.Semantic proximity Read ↗

Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis.Semantic proximity Read ↗

Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?Semantic proximity Read ↗

Pathways to gene identification in rheumatoid arthritis: PTPN22 and beyond.Semantic proximity Read ↗

Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis.Semantic proximity Read ↗

The PTPN22*C1858T functional polymorphism is associated with susceptibility to inflammatory polyarthritis but neither this nor other variants spanning the gene is associated with disease outcome.Semantic proximity Read ↗

A variant of PTPN22 gene conferring risk to autoimmune diseases may protect against tuberculosis.Semantic proximity Read ↗

Evidence for susceptibility determinant(s) to psoriasis vulgaris in or near PTPN22 in German patients.Semantic proximity Read ↗

Association of the PTPN22 C1858T single-nucleotide polymorphism with rheumatoid arthritis phenotypes in an inception cohort.Semantic proximity Read ↗

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