Article
The PTPN22*C1858T functional polymorphism is associated with susceptibility to inflammatory polyarthritis but neither this nor other variants spanning the gene is associated with disease outcome.
Annals of the rheumatic diseases - 1 Feb 2008
Naseem H, Thomson W, Silman A, Worthington J, Symmons D, Barton A
Abstract excerpt
BACKGROUND: The PTPN22 gene has been widely confirmed as a susceptibility gene for rheumatoid arthritis (RA) in populations of Northern European descent. The aim of the current study was to explore the role of variants spanning the PTPN22 gene in determining susceptibility to and outcome of inflammatory polyarthritis (IP). PATIENTS AND METHODS: Single nucleotide polymorphism (SNP) variants spanning the gene were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.