Article
Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis.
European journal of human genetics : EJHG - 1 Mar 2006
De Jager Philip L, Sawcer Stephen, Waliszewska Alicja, Farwell Lisa, Wild Gary, Cohen Albert, Langelier Diane, Bitton Alain, Compston Alastair, Hafler David A, Rioux John D
Abstract excerpt
The 620W allele of PTPN22 has been associated with susceptibility to several different forms of chronic inflammatory disease, including Type 1 diabetes (T1D), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and autoimmune thyroiditis (AIT). We set out to explore its possible role in two other inflammatory diseases: multiple sclerosis (MS) and Crohn's disease (CD). In our cohort of 496 MS trios from...
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