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Human antibodies for immunotherapy development generated via a human B cell hybridoma technology

27 Feb 2006

Abstract excerpt

Current strategies for the production of therapeutic mAbs include the use of mammalian cell systems to recombinantly produce Abs derived from mice bearing human Ig transgenes, humanization of rodent Abs, or phage libraries. Generation of hybridomas secreting human mAbs has been previously reported; however, this approach has not been fully exploited for immunotherapy development. We previously reported the use of...

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PMID: 16505368
DOI: 10.1073/pnas.0511285103

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