Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Method for generation of human hyperdiversified antibody fragment library.

Biotechnology journal - 1 Jan 2007

Mondon Philippe, Souyris Nathalie, Douchy Laurent, Crozet Fabien, Bouayadi Khalil, Kharrat Hakim

Abstract excerpt

The selection of antibody fragments from libraries using in vitro screening technologies has proven to be a very good alternative to the classical hybridoma technology, and has overcome the laborious process of antibody humanization. However, the complexity of the library is critical in the probability of being able to directly isolate a high affinity antibody specific to a target. We report a method to make...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to B-Lymphocytes
Share to Drug Delivery Systems

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin Fragments

Share to Mutation

Share to Peptide Library

Share to Protein Engineering

Source

Identifiers

PMID: 17225253
DOI: 10.1002/biot.200600205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Method for generation of human hyperdiversified antibody fragment library.PMID 17225253Read ↗

Human antibody libraries: A race to engineer and explore a larger diversitySemantic proximity Read ↗

A bioinformatics pipeline to build a knowledge database for in silico antibody engineering.Semantic proximity Read ↗

A novel platform to produce human monoclonal antibodies: The next generation of therapeutic human monoclonal antibodies discovery.Semantic proximity Read ↗

Cognizance of Molecular Methods for the Generation of Mutagenic Phage Display Antibody Libraries for Affinity MaturationSemantic proximity Read ↗

Mimicking somatic hypermutation: affinity maturation of antibodies displayed on bacteriophage using a bacterial mutator strain.Semantic proximity Read ↗

Generation, Diversity Determination, and Application to Antibody Selection of a Human Naïve Fab LibrarySemantic proximity Read ↗

Improving antibody affinity by mimicking somatic hypermutation in vitroSemantic proximity Read ↗

Antibody discovery and engineering by enhanced CRISPR-Cas9 integration of variable gene cassette libraries in mammalian cellsSemantic proximity Read ↗

A Novel Human scFv Library with Non-Combinatorial Synthetic CDR Diversity.Semantic proximity Read ↗

Natural Evolution of a Human Virus-Specific Antibody Gene Repertoire by Somatic Hypermutation Requires Both Hotspot-Directed and Randomly-Directed ProcessesSemantic proximity Read ↗

Antibody Engineering at the MillenniumSemantic proximity Read ↗

High-throughput generation and engineering of recombinant human antibodiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.