Article
Morphogenics as a tool for target discovery and drug development.
Annals of the New York Academy of Sciences - 1 Nov 2005
Nicolaides Nicholas C, Ebel Wolfgang, Kline Brad, Chao Qimin, Routhier Eric, Sass Philip M, Grasso Luigi
Abstract excerpt
Mutations in DNA mismatch repair (MMR) genes lead to genetically hypermutable cells. Germline mutations in MMR genes in man have been linked to the genetic predisposition to hereditary nonpolyposis colon cancer and a number of other inherited and sporadic malignancies. The ability to modulate the MMR process (referred to as morphogenics) in model systems offers a powerful tool for generating functional diversity...
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