Recent advances in the immunogenetics of human type 1 diabetes.

Abstract excerpt

Type 1 diabetes (T1D), a disorder of glucose homeostasis, is caused by autoimmune destruction of the essential insulin-secreting beta cells in the pancreas. Both genetic and environmental factors contribute to the risk of T1D and, for decades, this complexity has challenged investigators interested in identifying the genes that contribute to this risk. Nevertheless, in recent years, a number of well-supported T1D...

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