Article
Immunogenetics of type 1 diabetes.
Hormone research - 1 Jan 2005
Kim Mimi S, Polychronakos Constantin
Abstract excerpt
The T-cell mediated autoimmune process that destroys pancreatic beta cells in type 1 diabetes (T1D) is a complex phenotype influenced by multiple genetic and environmental factors. Human leukocyte antigen (HLA) accounts for about half of the genetic susceptibility, through a large variety of protective and predisposing haplotypes. Other important loci associated with T1D, with much smaller effects than HLA,...
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