Article
Phenotypic characterization of antigenic hybrids of poliovirus.
Microbial pathogenesis - 1 Jan 1991
Murdin A D, Kameda A, Murray M G, Wimmer E
Abstract excerpt
Three poliovirus hybrids, modified in neutralization antigenic sites (NAgs) I or II, were characterized for several phenotypic traits. The modifications to the capsid interfered with some stage of the life-cycle of the virus, since all three hybrids were growth-impaired in comparison to poliovirus type 1 (Mahoney) [PV1 (M)], the wild-type parent virus. All hybrids exhibited a reduced growth rate and a...
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