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Article

Antigenic evolution of vaccine-derived polioviruses: changes in individual epitopes and relative stability of the overall immunological properties.

Journal of virology - 1 Mar 2006

Yakovenko Maria L, Cherkasova Elena A, Rezapkin Gennady V, Ivanova Olga E, Ivanov Alexander P, Eremeeva Tatyana P, Baykova Olga Y, Chumakov Konstantin M, Agol Vadim I

Abstract excerpt

The Sabin oral poliovirus vaccine (OPV) readily undergoes changes in antigenic sites upon replication in humans. Here, a set of antigenically altered descendants of the three OPV serotypes (76 isolates) was characterized to determine the driving forces behind these changes and their biological implications. The amino acid residues of OPV derivatives that lie within or close to the known antigenic sites exhibited...

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Source

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Identifiers

PMID: 16501074
DOI: 10.1128/JVI.80.6.2641-2653.2006
PMCID: PMC1395452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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