Article
Sensitive determination of omeprazole and its two main metabolites in human plasma by column-switching high-performance liquid chromatography: application to pharmacokinetic study in relation to CYP2C19 genotypes.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences - 7 Mar 2006
Shimizu Mikiko, Uno Tsukasa, Niioka Takenori, Yaui-Furukori Norio, Takahata Takenori, Sugawara Kazunobu, Tateishi Tomonori
Abstract excerpt
A simple and sensitive column-switching high-performance liquid chromatographic method was developed for the simultaneous determination of omeprazole and its two main metabolites, 5-hydroxyomeprazole and omeprazole sulfone, in human plasma. Omeprazole, its two metabolites and lansoprazol as an internal standard were extracted from 1 ml of alkalinized plasma sample using diethyl ether-dichloromethane (45:55, v/v)....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.