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Article

Study of the effect of CYP2C19 polymorphisms on omeprazole pharmacokinetics by utilizing validated LC-MS/MS and Real Time-PCR methods.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences - 15 Mar 2017

Koukoula Maria, Dotsikas Yannis, Molou Elina, Schulpis Kleopatra H, Thodi Georgia, Chatzidaki Maria, Triantafylli Olga, Loukas Yannis L

Abstract excerpt

A fully automated liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the determination of omeprazole in human plasma. Utilization of 96-well plates and robotic liquid handling workstations, rendered the whole procedure very fast, compared to the manual respective procedure of Liquid-Liquid Extraction (LLE). Sample analysis was performed by reversed phase LC-MS/MS, with positive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27432733
DOI: 10.1016/j.jchromb.2016.06.046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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