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Comparative pharmacokinetics of Omeprazole and its metabolites in poor and extensive metabolizer Pakistani healthy volunteers and a review of different studies.

Pakistan journal of pharmaceutical sciences - 1 Jul 2018

Ahmad Lateef, Iqbal Zafar, Shah Yasar, Nazir Shabnam, Khan Abad, Khan Muhammad Imran, Khan Abbas, Khuda Fazli, Khan Ismail

Abstract excerpt

This study was designed to evaluate a comparative single dose (40mg) pharmacokinetics (PK) of Omeprazole (OMP) and its two metabolites, 5-hydroxy Omeprazole (5-OH-OMP) and Omeprazole sulphone (OMP-S) in poor (PM) and extensive (EM) metabolizer Pakistani healthy adult volunteers. The frequency of CYP2C19 and CYP3A4 varies widely in different populations. The present study was conducted to evaluate the PK of OMP...

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PMID: 30033421

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OMP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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