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Article

Chiral assay of omeprazole and metabolites and its application to a pharmacokinetics related to CYP2C19 genotypes.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences - 15 Aug 2011

Shiohira Hideo, Yasui-Furukori Norio, Tateishi Tomonori, Uno Tsukasa

Abstract excerpt

Studies investigating the relationship between CYP2C19 genotype and the stereoselective metabolism of omeprazole have not been reported. In the present study, we developed a simple and sensitive analytical method based on column switching reversed phase high-performance liquid chromatography (HPLC) with UV detection to determine the concentrations of (R)- and (S)-omeprazole and of its principal metabolites, (R)-...

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Identifiers

PMID: 21783435
DOI: 10.1016/j.jchromb.2011.06.046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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