Article

Live Cell Sorting of Differentiated Primary Human Osteoclasts Allows Generation of Transcriptomic Signature Matrix

2025-04-01

Abstract excerpt

<title>Abstract</title> <p>Osteoclasts are specialized cells that degrade the bone matrix to create space for bone regeneration. During tumorigenesis, cancer cells metastasize to bone by disrupting bone’s natural remodeling cycle. However, the mechanisms underlying critical bone-tumor interactions are poorly understood due to challenges in isolating osteoclasts from human bone. Thus, the conventional method to ob...

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Literature Corpus work: ee8d3c14-f5c3-5041-8fa1-b01ac0701ea4
DOI: 10.21203/rs.3.rs-6157400/v1

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