Article
Multinucleated osteoclast formation in vivo and in vitro by P2X7 receptor-deficient mice.
Critical reviews in eukaryotic gene expression - 1 Jan 2003
Gartland A, Buckley K A, Hipskind R A, Perry M J, Tobias J H, Buell G, Chessell I, Bowler W B, Gallagher J A
Abstract excerpt
The P2X7 receptor is a member of the family of P2X purinergic receptors, which upon sustained activation forms large pores in the plasma membrane. In cells of hematopoietic origin, P2X7 receptor activation has been shown to lead to multiple downstream events, including cytokine release, cell permeabilization, and apoptosis. This receptor has also been implicated in the generation of multinucleated giant cells,...
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